产品货号：
Z22172
中文名称：
NOXO1抗体
英文名称：
Anti-NOXO1 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NOXO1 Antibody |
| 指标别名 | NOXO1;NOXO-1;NOXO 1;NADPH oxidase organizer 1;NADPH oxidase regulatory protein;Nox organizer 1;Nox organizing protein 1;Regulatory protein P41NOX;SH3 and PX domain-containing protein 5;P41NOX;SH3PXD5 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,ELISA |
| 基因名称 | NOXO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human NOXO1 protein. |
| 计算分子量 | 41KD |
| 成分 | Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide. |
| 纯化方式 | NOXO1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | This antibody is suitable for Cancer,Immunology and Nuclear Signaling research.The enzymes NADPH oxidase (NOX) and dual oxidase (DUOX) generate ROS in a regulated manner,producing reactive oxygen in various cells and tissues in response to growth factors,cytokines and calcium signals.The oxidase consists of the catalytic subunit gp91phox (otherwise known as NOX2),together with the regulatory subunits p22phox,p47phox,p40phox,p67phox and the small GTPase RAC.The enzyme activity of gp91phox is regulated by the assembly of these regulatory subunits with gp91phox to form an active complex.In 1999,the first of the NOX homologues of gp91phox was described as NOX1.The enzyme was cloned from a colon epithelial cell complementary DNA library.When expressed in cells,NOX1 generated low amounts of ROS,but high-level ROS production by NOX1 was subsequently achieved by co-expression with novel regulatory subunits (described later).Subsequently,NOX3 and NOX4 were cloned,and the latter was shown to generate high levels of ROS when expressed in cells.NOX organizer 1 (NOXO1) is a homologue of p47phox and has an almost identical domain organization,except that it lacks the auto-inhibitory region.NOX activator 1 (NOXA1) is a homologue of p67phox and similarly shares the same domain organization,except that it lacks one of the two SH3 domains that are present in p67phox.Co-transfection of NOX1,NOXO1 and NOXA1 results in marked ROS generation.Similar to p47phox,NOXO1 binds to p22phox,which is required for NOX1-dependent activity.NOXA1 has a well-conserved activation domain,implying a conserved mechanism for regulating the activity of the target NOX enzyme. |
| Uniprot ID | Q8NFA2 |
| 基因名全称 | NADPH oxidase organizer 1 |
| 蛋白名全称 | NADPH oxidase organizer 1 |
| 推荐稀释比 | WB 1:500～2000 ELISA 1:5000～20000 |
相关搜索：NOXO1抗体，NOXO1多抗，Anti-NOXO1 Antibody